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First published online March 21, 2008
doi: 10.1242/10.1242/dev.018796

Development 135, 1389-1393 (2008)
Published by The Company of Biologists 2008
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A sugar rush for developmental biology

Catherine L. R. Merry1,* and Christopher M. Ward2

1 Materials Science Centre, The University of Manchester, Grosvenor Street, Manchester M1 7HS, UK.
2 Centre for Molecular Medicine, Lab. 3.722 Stopford Building, Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9PT, UK.


Figure 1
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  		Fig. 1. Mammalian glycan structures. Mammalian glycans discussed in the text are depicted using sugar symbols. (A) N-glycans; (B) mucin O-glycans; and (C) O-fucose glycans. The glycosyltransferase that initiates the transition shown is represented by its biochemical abbreviation and by its gene name (in parentheses). N-glycans (A) occur at NXS/T (where X is any amino acid) sequences, and O-glycans (B) at Ser or Thr (S/T). (C) O-FucT-1 transfers only to EGF (epidermal growth factor) repeats with a particular consensus sequence (Cys-Cys bonds, 1-6, are highlighted in yellow). A dashed line signifies that several reactions must occur before obtaining the product shown. A solid line designates a single reaction. Maternal and zygotic mutants of each glycosysyltransferase are discussed in the text. Fuc, fucose; Gal, galactose; Man, mannose; GalNAc, N-acetylgalactosamine; GlcNAc, N-acetylglucosamine. Image courtesy of Pamela Stanley.

 

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  		Fig. 2. The role of pgant35A during Drosophila tracheal development. (A) Schematic of a wild-type tracheal tube in cross section. (B) Cross section of a pgant35A maternal/zygotic (m/z) mutant tracheal tube, showing loss of apicobasal polarity and of the diffusion barrier (large arrow). Reproduced, with permission, from Tian and Ten Hagen (Tian and Ten Hagen, 2007bGo).

 

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