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First published online April 11, 2008
doi: 10.1242/10.1242/dev.019943

Development 135, 1569-1573 (2008)
Published by The Company of Biologists 2008
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Stem cell researchers find their niche

Elaine Dzierzak1 and Tariq Enver2

1 Erasmus Medical Center, Department of Cell Biology, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
2 MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DS, UK.


Figure 1
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  		Fig. 1. Asymmetric Numb segregation enables neural stem cells to balance self-renewal and differentiation during mouse neurogenesis. Mammalian Numb proteins localise to one side of the cell membrane in dividing neural stem (progenitor) cells and can be differentially inherited by the two daughter cells. (A) An immunofluorescent neural stem cell with Numb protein (green) localised asymmetrically. Red fluorescence indicates the chromosomes. (B) Schematic of a neural stem cell and its daughter cells, showing the localisation of Numb (green; apical localisation is shown in the neural stem cell). The daughter cell that inherits the most Numb self-renews, whereas the one that inherits less Numb becomes a neuron. Images courtesy of Weimin Zhong.

 

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  		Fig. 2 . Proliferation and differentiation in mouse small intestine. The proliferating compartment of an intestinal crypt of an adult mouse small intestine, as revealed by Ki67 immunohistochemistry (brown), which stains proliferating cells, and Alcian Blue staining, which detects mucosecretory differentiated cells. Image courtesy of Verónica Rodilla and Lluís Espinosa.

 

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© The Company of Biologists Ltd 2008