Fig. 10. Proposed model for gene interactions involved in the establishment of the territories of the vertebrate eye. (A,B) Schematic summaries of the distribution of eye patterning genes in wild-type and Otx1-/-; Otx2+/- mice at E9.5 and E12.5. Panels C and D suggest how genes necessary to confer the identity of one territory (i.e. Otx with the PE) may contribute to restrict the expression of genes necessary for the specification of the nearby regions (OS and NR). This model is based on the present findings and on the results reported in (1) Fuhrmann, 2000; (2) McDonald et al., 1995; (3) Nguyen and Arnheiter, 2000; (4) Schwarz et al., 2000 (see Discussion for details).
