Fig. 1. Loss of STAT1 function leads to correction of the long bone phenotype observed in TgFGF mice. Radiography of the long bones of wild-type (WT), Stat1-/-, TgFGF and TgFGF/Stat1-/- mice at 3 months of age (A). Femurs and tibia of TgFGF are shorter and thicker than in the WT and Stat1-/- mice. TgFGF/Stat1-/- bones are similar to the WT and Stat1-/-. (B) Histogram representation of the ratio between bone length (femurs) and bodyweight. Bodyweight was similar in all the groups analyzed. TgFGF femurs are significantly shorter than WT, Stat1-/- and TgFGF/Stat1-/-. Each histogram represents the average of six independent measurements performed on four mice in each group. Bars correspond to s.d.
