Fig. 6. The mitogenic response of OP cells to PDGF requires TN-C. (A)
Response of wild-type or TN-C-deficient OP cells to increasing
concentrations of the mitogen PDGF (0 to 10 ng/ml) when grown on
wild-type or TN-C-deficient astroglia matrix substrates. Results shown
represent mean±s.e.m. from at least three independent
experiments (WT, wild type; -/-, null; P value
was obtained using Student’s t test). Note the lack of
response of TN-C-null OP cells to PDGF at all concentrations on the
TN-C-null substrate. (B) The lack of proliferative response to PDGF in
the absence of TN-C is rescued by the addition of exogenous purified
TN-C (10 µg/ml) to the TN-C-null astroglia substrate
(Student’s t test: *P<0.05).
