Fig. 7. Requirement of the 
vß3 integrin for the potentiation by
TN-C of PDGF mitogenic effects. Rat OP cells were plated on PDL
substrata or on PDL substrata with exogenous purified TN-C
(PDL+TN-C) in the presence (F11(+)) or absence
(F11(-)) of a ß3 function-blocking monoclonal
antibody. Cells were then grown in the presence of different
concentrations of PDGF (1, 4, 7, 10: 0 ng/ml; 2, 5, 8, 11: 1 ng/ml; 3,
6, 9, 12: 10 ng/ml) for 18 hours before the addition of BrdU for 6
hours. Results represent mean±s.e.m. of three independent
experiments (Student’s t test:
*P<0.001, comparison between PDL and PDL+ TN-C;
°P<0.001, comparison between F11(+) and
F11(-)).
