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Fig. 3. Retarded differentiation of MBP-positive and PLP-positive oligodendrocytes in Nkx2.2 mutant spinal cords. Transverse sections from various stages of wild-type (A-I) and mutant (A'-I') littermates were hybridized with MBP (A-E) or PLP-DM20 (F-I) riboprobes by in situ hybridization. Note the reduced and delayed expression of MBP and PLP in the white matter and the lack of MBP-positive and PLP-positive cells in the gray matter of the mutant spinal cords.
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