Fig. 2. (A) Genomic clones of lin-48. Rectangles indicate exons of lin-48, with black areas corresponding to the sequences that code for the zinc-finger domain in B. Ovals indicate the position of regulatory elements lre1 and lre2 from Fig. 5. (B) lin-48 encodes an OVO zinc-finger protein. Alignment of the C2H2 zinc-finger domain from C. elegans LIN-48, Drosophila OVO and mouse OVO1 (mOVO1). Identical amino acids are highlighted in black, conserved amino acids in gray. The cysteines and histidines predicted to coordinate zinc ions are indicated with an asterisk. The amino acids affected by lin-48 mutations are indicated. sy548 is a GAC-to-TAC transversion. sa469 is a CAT-to-CGT transition. sy234 is a CCC-to-TCC transition.
