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Fig. 7. Relationship between Prx1/Prx2, Shh and cell proliferation in the E10.5 mandibular arch. Prx1 and Prx2 in medial mandibular arch mesenchyme regulate the production of an unknown signaling factor (?). This factor signals to the oral epithelium and stimulates the expression of Shh. Shh signals back to the mesenchyme and stimulates cell proliferation.





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