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Fig. 2. Morphology of Otx2{lambda}/Otx2{lambda} and Otx2{lambda}/- embryos. (A-J) When compared with wild-type (A,F), Otx2{lambda}/Otx2{lambda} embryos exhibited brain abnormalities, the majority of which were exencephaly, lack of closure of neural tube (B,G) or reduction of forebrain-midbrain (C,H); 90% of Otx2{lambda}/- embryos revealed a severe reduction of anterior CNS with an almost headless phenotype (D,I,J) and 10% of them a phenotype (E) similar to that of Otx2{lambda}/Otx2{lambda} mutants. Fb, forebrain; Hb, hindbrain; Mb, midbrain.





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