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Fig. 3. Distribution of Otx2{lambda} mRNA and protein during gastrulation. (A-L) Sagittal sections of 6.5 and 7.75 d.p.c. wild-type (A,A',E,E',I), Otx2+/- (B,B',F,F',J), Otx2{lambda}/Otx2{lambda} (C,C',G,G',K) and Otx2{lambda}/- (D,D',H,H',L) embryos hybridised with an Otx2- (A,B,E,F) and an Otx2{lambda} (C,D,G,H) -specific probe. There are no differences between Otx2 (A,B,E,F) and Otx2{lambda} (C,D,G,H) expression patterns. OTX2 protein levels are gradually reduced in the epiblast, anterior neuroectoderm and axial mesendoderm but not in the VE of Otx2{lambda}/Otx2{lambda} (C’,G’,K) and Otx2{lambda}/- (D’,H’,L) mutants (when compared with wild-type (A’,E’,I) and Otx2+/- (B’,F’,J) embryos. ame, axial mesendoderm; ane, anterior neuroectoderm; AVE, anterior visceral endoderm; epi, epiblast. (I-L) Magnifications of embryos in (E'-H').





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