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Fig. 3. Mitotic and cell death patterns in the second pharyngeal arch are not altered despite the loss of ncc. Wild-type (a,d), Hoxa1-/- (b,e) and Hoxa1-/-/Hoxb1 3'RARE-/- (c,f) embryos were processed for whole-mount immunohistochemical detection of mitosis (a-c) and cell death (d-f). (a-c) Reduced but considerable mitotic activity was still detected in the second pharyngeal arch (pa2) of both Hoxa1-/- and Hoxa1-/-/Hoxb1 3'RARE-/- embryos. (d-f) There was no increase of cell death in the second pharyngeal arch of either Hoxa1-/- or Hoxa1-/-/ Hoxa1-/- Hoxb1 3'RARE-/- embryos.





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