Fig. 2. Typical phenotypes of let-425 homozygotes (A-C), Nomarski images
of the animals at the L3 molt stage, when the induced vulval precursors cells
have divided to form four progeny. (A) Wild type, (B) homozygous
let-425 mutant animals and (C) a wild-type animal affected by
med-6 RNAi. (D,E) Nomarski images of the vulval tissue at the L4
stage, when invagination of the induced vulval precursor cells occurs. (D)
Wild type, (E) a homozygous let-425 mutant animal, showing an
abnormal invagination caused by less than wild-type induction of VPCs. (F)
Nomarski image of a homozygous let-425 mutant animal at the adult
stage. Hypo-induced VPCs have undergone morphogenesis and formed a protruding
vulva. Scale bar: 25 µm.
