Fig. 5. Immunohistochemical characterization of grafted MGE (A-C) and LGE (D-F) cells in the neocortex (NCx; A,B,F) and striatum (Str; C,D,E). MGE-derived cells are from a 4-month-old animal, LGE-derived cells are from 3-week-old animal. The second column and green color in the third column represent staining for alkaline phosphatase expressed in transplanted cells. (A-C) Many MGE cell in the neocortex expressed parvalbumin (A) and somatostatin (B) but within striatum did not express striatal marker DARPP-32 (C). (D,E) The majority of LGE cells in the striatum expressed DARPP-32 (D) but did not express parvalbumin (E). (F) By contrast, some of the LGE-derived neurons that migrated into the neocortex expressed parvalbumin.
