Fig. 5. Loss of phalangeal joints in homozygous ColII-FGFR31^ach transgenic mice at E17.5. (A-C) Hematoxylin stained forelimb digits 2 and 3. (D-F) In situ hybridization showing transgene (hGH) expression. In both ColII-FGFR31^ach transgenic line 1 (A,D) and line 2 (B,E), the joints in the second and third digits of the forefeet are completely lost and replaced with a single cartilaginous element. In homozygous ColII-FGFR3^ach transgenic mice (C,F), the proximal phalangeal joints develop normally (indicated by an arrow), but the distal phalangeal joint is fused (indicated by an arrowhead).

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