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Fig. 4. Cranial phenotype of newborn Alx3/Alx4lst-J double mutant mouse. Lateral (A-D) and frontal (E-H) views on crania of Alx3+/- (A,E), Alx4lst-J/lst-J (B,F), Alx3+/-/Alx4lst-J/lst-J (C,G) and Alx3-/-/Alx4lst-J/lst-J (D,H) newborn mice. The anterior region is truncated, the nose is split and the eyes are open in all mutants. Note abnormal appearance of skull vault, owing to reduced parietal frontal and nasal bones in D. The severity of the cleft nose phenotype is highly variable.





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