Fig. 6. fet is allelic to cic. (A-C) In the wild-type embryo (A), tll RNA expression is confined to the termini of the embryo. In embryos produced by fetT6/fetE11 females (B) and fetE11 GLC embryos (C), tll RNA expression is derepressed towards the center of the embryo. (Lateral view, dorsal side upwards). (D) Cuticle of embryo produced by fetU6/cic1 transheterozygote shows a torso gain-of-function phenotype. (E) RNA blot probed with cic cDNA probe. Each lane was loaded with 1 µg poly(A)+ ovarian RNA isolated from females with the indicated genotypes. Mobilities of DNA markers are indicated on left. The arrow points to the 5.7 kb cic transcript. (F) The intron/exon organization of the cic transcript, with black boxes representing the 13 exons. The HMG box lies within exon 3, and the conserved C-terminal domain is located within exons 11 and 12. The positions of mutations fetT6, fetU6, and fetE11 are indicated above the boxes. The location of the cic1 hobo insertion has been described to be in the 5' untranslated region (Jiménez et al., 2000).
