Fig. 9. A model for the regulation of Mef2c transcription during skeletal muscle development. (A) Regulation of Mef2c expression during myogenesis. The skeletal muscle regulatory region of Mef2c contains binding sites for myogenic bHLH and MEF2 proteins. The E-box is required for initiation and maintenance of Mef2c expression. By contrast, the MEF2 site is required for amplification and maintenance of Mef2c expression. (B) A model for the genetic network of myogenic bHLH and MEF2 factors during myogenesis.
