Fig. 7. Otx2^2c/Otx2^2c embryos exhibit similarities with otd^2FL/otd^2FL embryos in forebrain and midbrain patterning. (A-D’) Whole-mount in situ hybridisation of 8.5 d.p.c. wild-type (A-D) and Otx2^2c/Otx2^2c (A’-D’) embryos with Otx2 (A,A’), Fgf8 (B,B’), Gbx2 (C,C’) and Bf1 (D,D’). (E-H’) Adjacent sagittal sections of 10.5 d.p.c. wild-type (E-H) and Otx2^2c/Otx2^2c (E’-H’) embryos, immunostained with OTX2 (E,E’) or hybridised with Fgf8 (F,F’), Gbx2 (G,G’) and Bf1 (H,H’). Abbreviations as in the previous figures.

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