Fig. 2. Lysosomal storage in LAP/Acp5-deficient liver, spleen and kidney. (A,B) Semithin section of a liver of a 3.5 month old control (A) and LAP/Acp5-deficient (B) mouse. Vacuolated Kupffer cells are indicated by arrows. (C,D) Sections through a control and LAP/Acp5-deficient spleen. Numerous vacuolated macrophages are apparent in the double deficient mouse (arrowheads in D); S, sinus. (E,F) LAMP1 immunohistology of control (E) and LAP/Acp5-deficient (F) kidney, demonstrating an increased immunoreactivity in LAP/Acp5-deficient kidney. (G,H) Lectin staining (sWGA) of control (G) and LAP/Acp5-deficient liver (H); cv, central vein. Note the increased labelling of LAP/Acp5-deficient Kupffer cells. Scale bars: 15 µm in A,B; 25 µm in C,D; 400 µm in E,F; 30 µm in G,H.
