Fig. 5. Primary structure of Rib protein. (A) Diagram showing locations of BTB domain (residues 18-138, gray fill), Pipsqueak (PSQ) motif (367-415, white fill) and bipartite nuclear localization sequence (NLS, 395-412, 409-426). The positions and consequences of rib^P7, rib¹, rib², rib^z1 and rib^P16 mutations are indicated, as are locations of three peptides (P1,P2,P3) used to generate Rib antisera. (B) Sequence alignment of BTB domains of Rib, Longitudinals lacking (Lola), Bric à brac (Bab), Broad-complex (Broad), Tramtrack (Ttk), Pipsqueak (Psq) and Tyrosine kinase related (Tkr). Residues identical to Rib are shaded. Marks below sequence indicate residues identical (*) or similar (.) among proteins shown, or identical among all BTB domain proteins . Large black circle, locations of changes caused by rib^P7 mutation and rib² and rib^z1 mutations. (C) Sequence alignment of Psq motifs in Rib, Psq and Tkr. Large black circle, location of rib^P16 mutation.

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