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Fig. 4. Gbx2–/–; Otx2hOtx1/hOtx1 embryos have an anterior truncation and exencephaly. (A,B) Morphology of wild-type (left in A), Otx2hOtx1/hOtx1 (right in A) and Gbx2–/–; Otx2hOtx1/hOtx1 embryos (B) at E12.5. (C-E) Sagittal sections of wild-type (C), Otx2hOtx1/hOtx1 (D) and Gbx2–/–; Otx2hOtx1/hOtx1 embryos (F) at E12.5. The anterior structures of Otx2hOtx1/hOtx1 and Gbx2–/–; Otx2hOtx1/hOtx1 embryos are largely truncated. There is more anterior tissue, particularly head mesenchyme (asterisk) in Gbx2–/–; Otx2hOtx1/hOtx1 embryos than in Otx2hOtx1/hOtx1 embryos. There is an additional thin epithelium (bracket) extending from the presumptive hindbrain in Gbx2–/–; Otx2hOtx1/hOtx1 embryos. D,E are at a higher magnification than C. The junction between the spinal cord and hindbrain is marked by arrowheads. Cb, cerebellum; Dt, dorsal thalamus; IV, IVth ventricle; Mb, midbrain; Sc, spinal cord; Tel, telecephalon.





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