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Fig. 5. Mes-met genes are maintained and co-expressed in the anterior neuroectoderm of Gbx2–/–; Otx2hOtx1/hOtx1 embryos at E9.5. (A-H) Expression of Fgf8 (A,B), Wnt1 (C,D), En1 (E,F) and human OTX1 (G,H) in wild type (left column) and Gbx2–/–; Otx2hOtx1/hOtx1 embryos (right column) at E9.5. Fgf8 and En1 are strongly expressed in a broad anterior region of the double mutant embryos and their expression appears to co-localize with that of Wnt1 and human OTX1.





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