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Fig. 2. Removal of Smo reduces the growth of long bones. (A) A comparison of E18.5 limb skeletons of wild type, Smo conditional null and Ihhn/Ihhn embryos. FL, forelimb; HL, hindlimb. (B) Relative lengths of E18.5 long bones of Cre10; Smon/Smoc embryos compared with Ihhn/Ihhn and wild-type bones. T, tibia; F, fibula; U, ulna; H, humerus; S, scapula; n=7. (C) Growth of the limbs at postnatal day 3 (P3) and P9 in Cre10; Smon/Smoc (MT) versus wild-type (WT) mice.





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