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Fig. 2. Abnormal appearance of the kidneys of plc-{gamma}1–/– chimeric mouse. (A) Abdominal cavities of the control (right) and plc-{gamma}1–/– (left) chimeras. (B) Histopathology of the kidney from plc-{gamma}1–/– chimeric mice. The specimens of the kidney from plc-{gamma}1–/– chimeric mice were stained with Haematoxylin and Eosin. (C) In situ hybridization of the kidney with a Y-chromosome-specific probe. Dark spots show digoxigenin-positive plc-{gamma}1–/– cells. *Normal looking tubules were negative for digoxigenin signals. (D,E) Representative kidney glomeruli in the plc-{gamma}1–/– and control chimeras. The arrow indicates a sclerotic glomeruli.





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