Fig. 4. Comparison of tadpole stages of (A) anterior half embryos, (B) dorsal anterior quadrants, and (C) notochord/neural plate coisolates. Posterior is bottom right in all three panels. e, endoderm; br, anterior neural tissue that normally gives rise to the brain; arrows in A indicate epidermis. Arrows in B indicate disorganized notochord cells that lost contact with an external substrate. In all three panels, the extended neural plate lies out of focus beneath the notochord. Scale bar, 10 µm.

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