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Fig. 6. lacZ expression patterns in the lenses of {alpha}3 and {alpha}8 knockout mice. (A) A side view of an eye, stained for ß-gal, from an {alpha}8 heterozygous (+/–) knockout mouse. The lens equator is indicated by an arrow and anterior monolayer epithelium is blue. C, cornea; R, retina; O, optic nerve. B and C show lenses from adult {alpha}8+/– and {alpha}3+/– sibs, respectively, stained for ß-gal; anterior view. (D) An equatorial view of the {alpha}3+/– lens in C; an arrow indicates the lens equator. (E-G) {alpha}8+/–, wild-type (+/+) and {alpha}3+/– embryos at 14 dpc, respectively. (H-J) Magnified views of eyes of the embryos in E, F and G, respectively. Scale bars (A-G) 1 mm; (H-J) 250 µm.





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