Fig. 8. RNAi of either cdl-1 or the histone genes resuls in defects in chromosome condensation and segregation. Embryos co-stained with the anti-alpha tubulin antibody (red) and DAPI (green) are shown. (A,B) Wild type. (C,D) cdl-1(RNAi). (E,F) RNAi of the histone H2B gene. In wild type, chromosomes are properly condensed at metaphase (B right) and segregated at anaphase (B left) through telophase (A). In embryos in which CDL-1 or histones are depleted, chromosome bridges (C,D,F) and decondensed chromosomes at metaphase and anaphase (D,E) can be often observed. Scale bar, 10 µm.
