Fig. 6. Revised pathway for dauer formation and adult longevity. Proposed wild-type function is shown, with arrows indicating stimulation of activities and T-bars indicating inhibition, but the steps do not indicate direct protein interactions. "ON" or "OFF" activity states are given for conditions that promote dauer formation and adult longevity. daf-2 and daf-7 branches converge at daf-9. DAF-9 inhibits dauer formation and shortens life span by inactivating the DAF-12 nuclear receptor (NR). See Discussion for details.
