Fig. 4. Histological sections of normal (A,C) and Tcfap2c–/– (B,D-H) embryos at 7.5 d.p.c. Conceptuses were sectioned longitudinally along the antimesometrial-mesometrial (AM-M) axis of the deciduum, resulting in sagittal sections of the embryos in A,C-E,G,H. The Tcfap2c–/– mutant shown in B,F is misoriented with respect to the AM-M axis, resulting in a cross-section of the embryo. The mesometrial pole is located towards the top. Individual embryos are described in the text. The line in A,B represents the AM-M axis. The line in G represents the abnormal angle of the dorsoventral axis. Scale bars: 100 µm. Abbreviations: WT, wild type; ch, chorion; am, amnion; epc, ectoplacental cone; exe, extra-embryonic ectoderm; ee, embryonic ectoderm; gc, giant cell; pe, parietal endoderm; ve, visceral endoderm; de, deciduum; me, mesoderm; AM, antimesometrial pole; M, mesometrial pole; D, dorsal; V, ventral.
