Fig. 1. Comparison of the basic domain amino acid sequence of CeTwist and several other bHLH homologs. The amino acids from the basic region and surrounding sequence are shown. Sequences were obtained from the following references: CeTwist, C. elegans (Harfe et al., 1998b); dTwist, D. melanogaster (Thisse et al., 1988); hTwist, H. sapiens (Wang et al., 1997); mTwist, M. musculus (Wolf et al., 1991); xTwist, X. laevis (Hopwood et al., 1989); CeMyoD (Krause et al., 1990); CeE/DA (Krause et al., 1997). Percent values of bHLH identity include the comparison of amino acids across the basic region that is shown and the HLH region that is not shown. Numbers surrounding the amino acids correspond to amino acid numbers in each Twist homolog. The location of the n2170sd point mutation is indicated in blue. The bottom three lines indicate the single amino acid changes made in the CeTwist protein (in Fig. 4) corresponding to known mutations found in hTwist of individuals with Saethre-Chotzen syndrome (Howard et al., 1997; Rose et al., 1997; Paznekas et al., 1998).
