Fig. 8. Zebrafish Acvrl1 acts through the Smad1/5/8 pathway in cultured cells. P19 cells were transfected with a Smad2/3-responsive luciferase reporter, pA3-lux (A) or a Smad1/5/8-responsive luciferase reporter, pTLX2-lux (B), along with activated TGFß type I receptors, Hs-TGFBR1*, Hs-ACVRL1*, Hs-BMPR1B*, or Dr-acvrl1*. Each bar represents mean±s.e.m. from 2 independent luciferase assays performed on each of 3 independent wells of transfected cells. #Significantly different from basal activity, P<0.05.
