Fig. 1. Embryos labelled with CM1 antiserum. Anterior towards the left in these and subsequent figures. (A) Wild type, stage 12. (B) Wild type, stage 15. (C) In western blots, CM1 recognised cleaved Drice but not cleaved Dronc or DCP1. (D) Alignment of the putative p20/p10 linker regions from Drosophila caspases with the human caspase 3 peptide and with caspase 1 from S. frugiperda, for which cleavage has been demonstrated C-terminal to either aspartate residue (Ahmad et al., 1997). Residues identical to the 13-mer CM1 peptide shaded (gaps has been introduced to permit alignment of active sites and p20 C termini). Long pro-regions suggest Decay, Damm, Dredd, Dream and Dronc are likely to be regulated initiator caspases.
