Fig. 11. Onset of Emx1/2 double mutant neocortical defects. (A-C) Emx1 and (D-F) Emx2 expression in wild-type cortex at E11.5 (A,D) and at E15.5 (B,C,E,F). (C,F) Enlarged views of B,E at the marginal zone. (G-I) MAP2, (J-L) reelin and (M-O) calretinin expression in E12.5 (G-I) and E11.5 preplate (J-O). (P-R) Birthdate analysis of E11.5 pioneer neurons. BrdU was injected at E11.5, subsequently, the distribution of BrdU-positive cells was examined at E18.5. (G,J,M,P) Wild-type, (H,K,N,Q) Emx2^–/– and (I,L,O,R) Emx1^–/– Emx2^–/– cortices. Abbreviations as in Fig. 7. Scale bars, C and F 25 µm; others 100 µm.

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