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Fig. 5. Immunoblotting of protein extracts from cerebella of L7cre; PtenLoxP/LoxP, L7cre; PtenLoxP/+ En2cre; PtenLoxP/LoxP and wild-type mice. Increased levels of phospho-Akt are only detected when Pten is deleted on both alleles in Purkinje cells (L7cre; PtenLoxP/LoxP mice) or in all cells of the vermis (En2cre; PtenLoxP/LoxP), while wild-type and L7cre; PtenLoxP/+ cerebella show no difference.





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