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Fig. 8. Altered distributions of Hoxd11 (A-E) and Hoxd12 (F-J) transcripts in the Raldh2–/– forelimbs. In mutants, deregulated expression along the forelimb AP axis is seen prior to the formation of the autopod (A,B,F,G: E9.5). Later on (C-E,H-J: E11.5), both the autopodal (arrowheads) and non-autopodal (arrows) expression domains extend ectopically along the anterior margin of the mutant limbs.





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