Fig. 5. her1 and her7 are partially redundant. (A-C) Confocal micrographs, side views of embryos stained for ß-catenin to outline cell boundaries. A', B' and C' are non-colorized versions of the confocal micrographs. (A) The first 2-3 somites in her1 MO-injected embryos (15 somite stage) are disrupted. The arrowhead denotes an attempt at a somite boundary that does not extend fully in either the mediolateral or dorsoventral dimensions. All other boundaries appear normal. (B) While anterior somites are normal in her7 MO-injected embryos (15 somite stage), posterior somites are enlarged. The first somite shown is somite 9. (C) Interior boundaries partially recover over time in her7 MO-injected embryos (22 somite stage). Strong boundaries are highlighted in blue. Weak boundaries are shown in red. (D-I) deltaD expression correlates with abnormal somite morphology in her7 MO-injected embryos. Early deltaD expression (2 somite stage) is unaffected in her7 MO-injected embryos compared to control embryos (D,E), but later (10 somite stage), deltaD expression is disrupted (F,I) similar to her1+7 MO-injected embryos (G). Interestingly, presomitic mesoderm expression of deltaD is partially disrupted in her1 MO-injected embryos (H), but somite morphology is normal posterior to somite 3 (A).

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