Fig. 1. Noggin-treated lens explants have reduced development of primary lens fiber cells. E10.5 mouse eye primordia were explanted into collagen gel in culture either in the absence [A (red bar) and B] or presence [A (blue bar), C,D] of the Bmp inhibitor noggin at 300 ng/ml. Quantification of the area of the largest lens section (in a series) in control and experimental explants indicated that noggin treatment reduced lens growth (A). At this stage of development, primary lens fiber cells make up most of the area in a lens section. The larger size and improved development of primary lens fiber cells in untreated explants (B) can be observed by comparison with those that were noggin-treated (C,D).

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