Fig. 8. Model for the asymmetrical distribution of primary fiber cell differentiation stimuli in the developing eye. In this model, we propose that there are two distinct stimuli that direct primary fiber cell differentiation. In the ventronasal quadrant of the developing eye, we suggest, based on the phenotype observed in the A-Alk6^DN and EE-1.0-K-Alk6^DN transgenic mice, that there is a Bmp ligand that can be inhibited by Alk6^DN. We suggest that there must be other primary fiber cell differentiation stimuli that are not inhibited by Alk6^DN.

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