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Fig. 1. Targeted disruption of the Fgfr2IIIc transcriptional alternative. (A) Genomic structure and targeting events; exons are shaded, with the exon number above, and the protein domain name underneath. {chi} and {gamma}, 5' and 3' probes respectively; B, BamHI; H, HindIII; RI, EcoRI; S, SacI; TM, transmembrane exon; #, site of point mutation. (B) DNA sequence of the region used for site-directed mutagenesis, showing the newly formed HindIII site and the translational stop codon (*). (C) Southern blot analysis of the homologous recombinant ES cells, probed with the 5' and 3' fragments designated in A.





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