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Fig. 11. Diminished expression of chondrocyte and osteocyte markers in the Fgfr2IIIc mutant. (A-L) Skull base at P1. (M-P) Tibia at P7. Cbfa1 and PTHrP expression are greatly decreased in the mutant; the Ihh expression domain is reduced, reflecting the reduced size of proliferating chondrocyte zones in both the skull base (I-L) and the tibial growth plate (M-P). hc, hypertrophic chondrocyte zone; pit, pituitary; pc, proliferating chondrocyte zone; rc, resting chondrocyte zone; tr, trabecular bone.





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