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Fig. 3. Localization of Fgfr2IIIc transcripts in skeletogenic tissues. (A,B) In the E12.5 limb bud, Fgfr2IIIc transcripts are in skeletogenic mesenchymal condensations. (C,D) In the E14.5 tibia, transcripts are localized to the perichondrium (periosteal collar) and nascent epiphyseal plate. (E,F) In the E18.5 skull base, transcripts are in the perichondrium and ossification zone. ep, position of future epiphyseal plate; hc, hypertrophic chondrocyte zone; pc, proliferating chondrocyte zone; pit, pituitary, po, periosteal collar; rc, resting chondrocyte zone; tr, trabecular bone.





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