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Fig. 3. Histologic analyses of the spina bifida and ectopic neural tubes in transgenic mice. (A,B) Transverse sections through the lumbo-sacral level of the spinal cord showing the histological features of the spina bifida (A) and an ectopic neural tube (B) in E12.5 transgenic embryos. Dorsal root ganglia are indicated by the arrows. (C,D) View of the filum terminale (ft) in 1-monthold wild-type (C) and transgenic (D) spinal cord. Note the presence of a lipoma (lp) in the transgenic spinal cord. (E) Transverse section of the adult transgenic spinal cord illustrating the attached lipoma and the split cord. cc, central canal; A,B,E, Hematoxylin and Eosin staining. Bars: 100 µm.





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