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Fig. 4. Magnetic resonance images of fixed, whole-mount transgenic embryos. The serial MRI transverse sections of an E16.5 transgenic embryo are arranged in a rostral (A) to caudal (D) series. The ectopic neural tubes (arrows) emerge ventrally from the spinal cord in the vicinity of the posterior neuropore (D) and proceed rostrally with progressively diminishing caliber to the level of the kidneys (A-C). The arrowheads in C and D indicate the area of spina bifida with a lesion in the surface ectoderm.





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