Fig. 5. pygo encodes a novel putative nuclear protein with a PHD finger domain. The amino acid sequence of Drosophila Pygo is shown in (A). A putative nuclear localization signal (NLS) is found in the N-terminal region (blue) and a PHD finger is found in C-terminal region (red). Three pygo mutants were sequenced and the mutations (green bars) are shown in B. Homologs of Pygo are also found in Xenopus and Mus musculus (B). They all have a NLS (blue box) at the N terminus and a PHD domain (red box) at the C terminus. The C-terminal regions of the four proteins are very conserved, and the alignment is show in C, which includes the PHD domains and the flanking sequences. The identical residues among four proteins are shown in pink and the similar residues are boxed (C).

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