Fig. 1. Mutations in SoxN result in the loss of neurons/GMCs and cause multiple morphological defects. (A-D) Immunostaining with anti-Eve antibody. Dorsal view of (A) wild type and (B) SoxN dissected stage 16 embryos. Arrows indicate the RP2 neuron (A) or the RP2 neuron position (B); arrowheads mark the EL neuron cluster (A) or the position of the EL neuron cluster (B). Ventral view of (C) wild-type and (D) SoxN whole-mount embryos. Arrows indicate GMC4-2a (C) or the GMC4-2a position (D). (E) Wild-type and (F) SoxN stage 11 embryos stained with anti-Ftz antibody. Brackets encompass one hemisegment each. Note the drastic loss of neurons/GMCs in intermediate and lateral regions of the CNS in F. (G,H) Ventral view of the cuticle of first instar larva, (G) wild-type and (H) SoxN. Arrowheads indicate a denticle belt. Note the reduction of the denticle belts along the AP axis in H. (I,J) Lateral view of stage17 whole-mount embryos. (I) Wild type and (J) SoxN. Note the defects in head and gut formation in J. Anterior is towards the left.

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