Fig. 2. Prop1 normally represses dorsal growth and activates ventral expansion. Midsagittal sections of embryos collected at E14.5 were stained with H&E to reveal the dorsal overgrowth in Prop1^df/df (B) relative to wild type (A) and Lhx4^–/– (C). The anterior lobe is marked with a bracket. Limited anterior lobe expansion is evident in Prop1 and Lhx4 mutants, but no anterior lobe development is detected in Prop1^df/df, Lhx4^–/– double mutants (D-G) in sections spanning the lateral through midsagittal regions. The number of lumens is increased in double mutants relative to any of the other genotypes.

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