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Fig. 3. Corticotropes and {alpha}GSU expressing cells fail to develop in double mutants. Immunohistochemical detection of LHX3 (A-D), ACTH (E-H), and {alpha}GSU (I-L) in sagittal sections of embryos of each genotype at E14.5 reveal the lack of cell specification in double mutants. LHX3 immunoreactivity is present throughout the entire Rathke’s pouch of wild type (A) Prop1df/df (B), Lhx4–/– (C) and double mutants (D). However, ACTH is not detectable in the double mutants (H) compared to the other genotypes (E-G). Similarly {alpha}GSU is absent in double mutants (L) but is present in the other genotypes (I-K). In these sections, anterior lobe is marked with a bracket and intermediate lobe with a curved bracket.





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