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Fig. 5. Proliferation in Rathke’s pouch at E12.5 and E14.5 is unaffected in mice lacking Prop1, Lhx4, or in double mutants. Immunostaining of BrdU-injected embryos was performed to assess proliferation levels in the pituitary mutants at E12.5 (A-D) and at E14.5 (E-G). Wild-type (A,E), Prop1df/df (B,F), Lhx4–/– (C,G) and Prop1df/dfLhx4–/– (D) mice all had dividing cells in the pituitary primordium. The anterior lobe is indicated with a bracket.





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