Fig. 2. Altered morphogenesis of the ciliary epithelium in CPV2-Noggin transgenic mice. In P1 wild-type (WT) eyes (A), the ciliary epithelium (CE) had become a thin monolayer of cells distinct from the neural retina (NR). A clear boundary had formed between these two tissues (arrow in A). In CPV2-Noggin transgenic (TG) mice at P1, the CE had either become thickened (B) or was completed disrupted (C). In the latter case, a lump of cells resembling retinal ganglion cells replaced the presumptive CE (C). The boundary between the retinal cells and those of the presumptive ciliary epithelium became less distinct (arrows in B,C). In P7 wild-type eyes (D), the CE became thinner and had started to fold. The presumptive CE in P7 transgenic mice had defects similar to those in the P1 eyes, either thickened (E) or totally altered (F). Abbreviations: L, lens; IE, iris epithelium. Scale bars: 100 µm.

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